Peptide Modifications advanced
Peptide Ubiquitination Sites
Explore ubiquitin conjugation to lysine residues and its role in peptide degradation.
By Encyclopeptide Editorial | 1 min read
ubiquitin proteasome degradation modification
Overview
Ubiquitination attaches ubiquitin to lysine residues, targeting proteins for proteasomal degradation or modulating signaling.
Chain Types
- K48-linked: Proteasomal degradation signal
- K63-linked: Signal transduction and DNA repair
- Linear/M1: NF-kB signaling
- Monoubiquitination: Endocytosis and histone regulation
Biological Significance
The ubiquitin-proteasome system is a major drug target. Proteasome inhibitors (bortezomib) treat multiple myeloma.
References
- Source: ENCP Peptide Database
- Category: Peptide Modifications
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