Therapeutic Peptides advanced
Zinc-Binding Group Peptides
Peptides containing zinc-binding pharmacophores for metalloprotease inhibition including hydroxamates, carboxylates, and thiols.
By Encyclopeptide Editorial | 1 min read
zinc-binding metalloprotease hydroxamate pharmacophore enzyme-inhibitor
Overview
Zinc-binding groups (ZBGs) are pharmacophoric moieties that coordinate with catalytic zinc ions in metalloproteases. They are essential components of many enzyme inhibitor drugs.
Common Zinc-Binding Groups
| ZBG | Zinc Coordination | Selectivity | Stability |
|---|---|---|---|
| Hydroxamate | Bidentate | Moderate | Moderate |
| Carboxylate | Bidentate | High | High |
| Thiol | Bidentate | High | Low (redox) |
| Phosphinate | Bidentate | High | High |
| N-hydroxyamide | Bidentate | Moderate | Moderate |
Therapeutic Applications
- Matrix metalloproteinase inhibitors: Marimastat, batimastat
- ACE inhibitors: Enalapril, lisinopril (carboxylate)
- Histone deacetylase inhibitors: Vorinostat (hydroxamate)
- Proteasome inhibitors: Bortezomib (boronic acid, analogous)
Chemical Identity
| Property | Value |
|---|---|
| Name | Zinc-Binding Group Peptides |
| Category | Therapeutic Peptides |
References
- Encyclopeptide Database. “Zinc-Binding Group Peptides” monograph. encyclopeptide.com.
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