GLP-1 Family intermediate
Exenatide Twice Daily
First-in-class short-acting GLP-1 receptor agonist derived from Gila monster exendin-4, administered twice daily.
By Encyclopeptide Editorial | 1 min read
exenatide GLP-1 exendin-4 twice-daily diabetes
Chemical Identity
| Property | Value |
|---|---|
| Chemical Formula | C149H225N43O65S |
| Molecular Weight | 4193.52 g/mol |
| CAS Number | 141732-76-5 |
| Product Name | Byetta |
| Peptide Class | Exendin-4 analog |
Structure
Exenatide is a 39-amino acid peptide identical to exendin-4, originally isolated from the Gila monster venom. It shares 53% sequence homology with human GLP-1 but is resistant to DPP-4 degradation.
Pharmacokinetics
- Half-life: 2.4 hours
- Onset: 30 minutes
- Peak: 2.1 hours
- Duration: 6-8 hours
- Dosing: Twice daily, within 60 minutes before meals
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “Exenatide Twice Daily” monograph. encyclopeptide.com.
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