GLP-1 Family beginner
The Incretin Effect
Physiological phenomenon where oral glucose produces greater insulin secretion than intravenous glucose, mediated by GLP-1 and GIP.
By Encyclopeptide Editorial | 1 min read
incretin GLP-1 GIP oral-glucose insulin-secretion
Magnitude of Incretin Effect
| Parameter | Oral Glucose | IV Glucose | Difference |
|---|---|---|---|
| Insulin AUC | 100% | 50-60% | 40-50% |
| Glucagon response | Suppressed | Minimal | Significant |
Physiological Mechanism
- Nutrient sensing by intestinal cells
- GLP-1 secretion from L-cells
- GIP secretion from K-cells
- Pancreatic activation by incretins
- Glucose-dependent insulin enhancement
Chemical Identity
| Property | Value |
|---|---|
| Name | The Incretin Effect |
| Category | GLP-1 Family |
Biological Significance
This molecule plays important roles in biological systems and has potential therapeutic applications.
References
- Encyclopeptide Database. “The Incretin Effect” monograph. encyclopeptide.com.
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